Antimicrobial resistance (AMR) is global health threat. The causes and contributors to AMR vary, but include selective pressures by the overuse of antibiotics, genetic elements and substandard infection prevention and control practices. Infection Disease and Health is primarily concerned with the prevention and control of infections in human health. In this, the first virtual special issue of the journal, we have compiled a selection of articles that are related to one of the biggest challenges of our time – AMR. The articles included in this special issue include a broad range of topics, from antimicrobial stewardship, knowledge and attitudes towards antibiotics, prescribing practices and cost. Articles cover a diverse range of health settings, including hospitals, general practice and broader public health considerations. The special issue provides a great example of how the journal serves as an important platform for health research and uniquely contributes to the infection prevention and control agenda internationally.