- •SN coating reduced the bioburden on both low and high contamination surfaces.
- •Effect of SN coating on environmental surfaces becomes more prominent with time.
- •Isolation of Acinetobacter species from SN coated surfaces was significantly reduced.
A nano-scale surface coating containing silicon nanoparticles (Bacterlon®) creates a hydrophobic surface which prevents the growth of bacteria. Study objective was to evaluate the performance of this silicon nano-coating in Sri Lankan healthcare setting.
This prospective study was conducted from September 2015 to December 2015 in an Intensive Care Unit and a medical ward in Base Hospital Homagama and a bacteriology laboratory in Medical Research Institute, Colombo, Sri Lanka. Silicon nanoparticle coating was applied to 19 high touch surfaces from those three sites. During the follow-up period, these test sites and non-coated control sites were used for routine work and were cleaned routinely as per institute protocol. Swabbing was done for coated and non-coated sites once a week for 12 weeks at unannounced times. Surfaces were categorized in to low (≤10 CFU/cm2) and high (>10–99 CFU/cm2) contamination by Aerobic Bacterial Count (ABC) in non-coated sites at any given time.
In low and high contaminated surfaces, an improvement in the mean percentage bioburden reduction from 36.18% to 50.16% was observed from 4th week to 12th week with silicon nanoparticles and a significant reduction (p < 0.05) was seen in ABC in each of the coated surface compared with their non-coated counterpart by the 12th week. The frequency of isolation of Acinetobacter spp. on coated surfaces had a significant reduction (p < 0.01).
Silicon nanoparticle coating demonstrates a significant reduction of the bacterial bioburden in low and high contaminated surfaces for 12 weeks in a tropical healthcare setting.
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- Healthcare-associated infections acquired in intensive care units.in: ECDC. Annual epidemiological report for 2015. ECDC, Stockholm2017https://ecdc.europa.eu/sites/portal/files/documents/AER_for_2015-healthcare-associated-infections_0.pdfDate accessed: January 8, 2019
- Prevalence study of hospital-acquired infections in 14 Greek hospitals: planning from the local to the national surveillance level.J Hosp Infect. 2002; 50: 269-275https://doi.org/10.1053/jhin.2002.1181
- Targeted surveillance of nosocomial infection in intensive care units of 176 hospitals in Jiangsu province, China.J Hosp Infect. 2018; 99: 36-41https://doi.org/10.1016/j.jhin.2017.10.009
- Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the national healthcare safety network at the centers for disease control and prevention, 2006–2007.Infect Control Hosp Epidemiol. 2008; 29: 996-1011https://doi.org/10.1086/591861
- Analysis of urine culture isolates from seven laboratories of Sri Lanka: national laboratory based surveillance of Sri Lanka college of microbiologists in 2014.Sri Lankan J Infect Dis. 2016; 6: 17https://doi.org/10.4038/sljid.v6i1.8105
- Spread of resistant gram negatives in a Sri Lankan intensive care unit.BMC Infect Dis. 2017; 17: 490https://doi.org/10.1186/s12879-017-2590-7
- A multi centre laboratory study of Gram negative bacterial blood stream infections in Sri Lanka.Ceylon Med J. 2013; 58: 56https://doi.org/10.4038/cmj.v58i2.5680
- Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study.The Lancet (London, England). 2017; 389: 805-814https://doi.org/10.1016/S0140-6736(16)31588-4
- A study of the relationship between environmental contamination with methicillin-resistant Staphylococcus aureus (MRSA) and patients' acquisition of MRSA.Infect Control Hosp Epidemiol. 2006; 27: 127-132https://doi.org/10.1086/500622
- The role of the healthcare environment in the spread of multidrug-resistant organisms: update on current best practices for containment.Ther Adv Infect Dis. 2014; 2: 79-90https://doi.org/10.1177/2049936114543287
- Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning.Lancet Infect Dis. 2008; 8: 101-113https://doi.org/10.1016/S1473-3099(07)70241-4
- Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants.Arch Intern Med. 2011; 17: 491-494https://doi.org/10.1001/archinternmed.2011.64
- Environmental disinfection with photocatalyst as an adjunctive measure to control transmission of methicillin-resistant Staphylococcus aureus: a prospective cohort study in a high-incidence setting.BMC Infect Dis. 2018; 18: 610https://doi.org/10.1186/s12879-018-3555-1
- Occupational exposure to disinfectants and asthma control in US nurses.Eur Respir J. 2017; 50: 1700237https://doi.org/10.1183/13993003.00237-2017
- Update on asthma and cleaning agents.Curr Opin Allergy Clin Immunol. 2017; 17: 90-95https://doi.org/10.1097/ACI.0000000000000349
- Symptoms in health personnel exposed to disinfectants.East Afr Med J. 2001; 78: 157-160
- Antimicrobial Nanoparticles: applications and mechanisms of action.Sri Lankan J Infect Dis. 2018; 8: 2https://doi.org/10.4038/sljid.v8i1.8167
- The antimicrobial activity of nanoparticles: present situation and prospects for the future.Int J Nanomed. 2017; 12: 1227-1249https://doi.org/10.2147/IJN.S121956
- Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials.Appl Microbiol Biotechnol. 2018; 102: 2075-2089https://doi.org/10.1007/s00253-018-8776-0
- Nanoparticles as antimicrobial agents: their toxicity and mechanisms of action.J Nanosci Nanotechnol. 2014; 14: 946-957
- Nanotechnology as a therapeutic tool to combat microbial resistance.Adv Drug Deliv Rev. 2013; 65: 1803-1815https://doi.org/10.1016/J.ADDR.2013.07.011
- P184: production and efficacy testing of antimicrobial fabrics for use in hospitals.Antimicrob Resist Infect Contr. 2013; 2: P184https://doi.org/10.1186/2047-2994-2-S1-P184
- Silver-nanoparticle-embedded antimicrobial paints based on vegetable oil.Nat Mater. 2008; 7: 236-241https://doi.org/10.1038/nmat2099
- Antibacterial silver-containing silica glass prepared by ion implantation.J Nanosci Nanotechnol. 2010; 10: 6424-6427
- Antimicrobial effect of biocompatible silicon nanoparticles activated using therapeutic ultrasound.Langmuir. 2017; 33: 2603-2609https://doi.org/10.1021/acs.langmuir.6b04303
- A microbiological evaluation of SiO2 -coated textiles in hospital interiors: the effect of passive coatings on the cleaning potential of interior textiles.J Ind Text. 2016; 46: 361-371https://doi.org/10.1177/1528083715580543
- Contamination, disinfection, and cross-colonization: are hospital surfaces reservoirs for nosocomial infection?.Clin Infect Dis. 2004; 39: 1182-1189https://doi.org/10.1086/424667
- Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients.Infect Control Hosp Epidemiol. 2011; 32: 185-187https://doi.org/10.1086/657944
- Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant Enterococcus or the colonized patients' environment.Infect Control Hosp Epidemiol. 2008; 29: 149-154https://doi.org/10.1086/524331
- Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms.Am J Infect Contr. 2012; 40: 556-558https://doi.org/10.1016/j.ajic.2011.08.002
- How long do nosocomial pathogens persist on inanimate surfaces? A systematic review.BMC Infect Dis. 2006; 6: 130https://doi.org/10.1186/1471-2334-6-130
- Correlation between the genetic diversity of nosocomial pathogens and their survival time in intensive care units.J Hosp Infect. 2006; 62: 181-186https://doi.org/10.1016/j.jhin.2005.08.010
- Cleaning hospital room surfaces to prevent health care-associated infections: a technical brief.Ann Intern Med. 2015; 163: 598-607https://doi.org/10.7326/M15-1192
- Smart solutions for HCAI—evaluation report: NanoPool surface coating.https://webarchive.nationalarchives.gov.uk/20120118172105/http://hcai.dh.gov.uk/files/2011/03/Nanopool_Evaluation_Report.pdfDate accessed: December 13, 2018
Published online: July 16, 2019
Accepted: June 26, 2019
Received in revised form: June 26, 2019
Received: April 17, 2019
© 2019 Australasian College for Infection Prevention and Control. Published by Elsevier B.V. All rights reserved.